Cas9/guide RNA (gRNA)‐based gene drive systems are expected to play a transformative role in malaria elimination efforts., whether through population modification, in which the drive system contains parasite‐refractory genes, or population suppression, in which the drive system induces a severe fitness load resulting in population decline or extinction. DNA sequence polymorphisms representing alternate alleles at gRNA target sites may confer a drive‐resistant phenotype in individuals carrying them. Modeling predicts that, for observed levels of SGV at potential target sites and observed (...) rates of de novo DRA formation, population modification strategies are uniquely resilient to DRAs. We conclude that gene drives can succeed when fitness costs incurred by drive‐carrying mosquitoes are low enough to prevent strong positive selection for DRAs produced de novo or as part of the SGV and that population modification strategies are less prone to failure due to drive resistance. (shrink)

Research misconduct is harmful because it threatens public health and public safety, and also undermines public confidence in science. Efforts to eradicate ongoing and prevent future misconduct are numerous and varied, yet the question of “what works” remains largely unanswered. To shed light on this issue, this study used data from both mail and online surveys administered to a stratified random sample of tenured and tenure-track faculty members (N = 613) in the social, natural, and applied sciences at America’s top (...) 100 research universities. Participants were asked to gauge the effectiveness of various intervention strategies: formal sanctions (professional and legal), informal sanctions (peers), prevention efforts (ethics and professional training), and reducing the pressures associated with working in research-intensive units. Results indicated that (1) formal sanctions received the highest level of support, (2) female scholars and researchers working in the applied sciences favored formal sanctions, and (3) a nontrivial portion of the sample supported an integrated approach that combined elements of different strategies. A key takeaway for university administrators is that a multifaceted approach to dealing with the problem of research misconduct, which prominently features enhanced formal sanctions, will be met with the support of university faculty. (shrink)

Social avoidance behaviour significantly interferes with social engagement and characterises various psychopathologies. Dual-process models propose that social behaviour is directed in part b...

Academic medical ethics must be a bulwark against a disturbing trend toward post-truth cultures. Activism of course has its place in massive cultural debates like abortion. The fact that so many people care so deeply about these debates is part of what makes them so important. But especially when coming from clinicians, academics, and others to whom we entrust the care of our public discourse, interventions into the debates must be disciplined by a thoroughgoing commitment to engage with the available (...) data to back up the central claims even when those claims seem like common sense—perhaps especially when they seem like common sense. (shrink)

This is a review of John McDowell's first two collections of essays. It stresses their considerble virtues. There is another version of the same material in French in Autour de L'esprit et le monde de John McDowell, Paris: Vrin, 2012 (eds. Anne le Goff and Christophe AL-Saleh).

In this paper we suggest that differing approaches to the science of social cognition mirror the arguments between radical embodied and traditional approaches to cognition. We contrast the use in social cognition of theoretical inference and mental simulation mechanisms with approaches emphasizing a direct perception of others’ mental states. We build from a recent integrative framework unifying these divergent perspectives through the use of dual-process theory and supporting social neuroscience research. Our elaboration considers two complementary notions of direct perception: one (...) primarily stemming from ecological psychology and the other from enactive cognition theory. We use this as the foundation from which to offer an account of the informational basis for social information and assert a set of research propositions to further the science of social cognition. In doing so, we point out how perception of the minds of others can be supported in some cases by lawful information, supporting direct perception of social affordances and perhaps, mental states, and in other cases by cues that support indirect perceptual inference. Our goal is to extend accounts of social cognition by integrating advances across disciplines to provide a multi-level and multi-theoretic description that can advance this field and offer a means through which to reconcile radical embodied and traditional approaches to cognitive neuroscience. (shrink)

Health promotion involves social and environmental interventions designed to benefit and protect health. It often harmfully impacts the environment through air and water pollution, medical waste, g...

This book provides practical and research-based chapters that offer greater clarity about the particular kinds of teacher reflection that matter and avoids talking about teacher reflection generically, which implies that all kinds of reflection are of equal value.

Can one be fooled into believing that one intended an action that one in fact did not intend? Past experimental paradigms have demonstrated that participants, when provided with false perceptual feedback about their actions, can be fooled into misperceiving the nature of their intended motor act. However, because veridical proprioceptive/perceptual feedback limits the extent to which participants can be fooled, few studies have been able to answer our question and induce the illusion to intend. In a novel paradigm addressing this (...) question, participants were instructed to move a line on the computer screen by use of a phony brain–computer interface. Line movements were actually controlled by computer program. Demonstrating the illusion to intend, participants reported more intentions to move the line when it moved frequently than when it moved infrequently. Consistent with ideomotor theory, the finding illuminates the intimate liaisons among ideomotor processing, the sense of agency, and action production. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

BackgroundThe process of peer-review in academia has attracted criticism surrounding issues of bias, fairness, and professionalism; however, frequency of occurrence of such comments is unknown.MethodsWe evaluated 1491 sets of reviewer comments from the fields of “Ecology and Evolution” and “Behavioural Medicine,” of which 920 were retrieved from the online review repository Publons and 571 were obtained from six early career investigators. Comment sets were coded for the occurrence of “unprofessional comments” and “incomplete, inaccurate or unsubstantiated critiques” using an a-prior rubric (...) based on our published research. Results are presented as absolute numbers and percentages.ResultsOverall, 12% of comment sets included at least one unprofessional comment towards the author or their work, and 41% contained incomplete, inaccurate of unsubstantiated critiques.ConclusionsThe large number of unprofessional comments, and IIUCs observed could heighten psychological distress among investigators, particularly those at an early stage in their career. We suggest that development and adherence to a universally agreed upon reviewer code of conduct is necessary to improve the quality and professional experience of peer review. (shrink)

Our recent paper reported that 43% of reviewer comment sets shared with authors contained at least one unprofessional comment or an incomplete, inaccurate of unsubstantiated critique. Publication of this work sparked an online conversation surrounding professionalism in peer review. We collected and analyzed these social media comments as they offered real-time responses to our work and provided insight into the views held by commenters and potential peer-reviewers that would be difficult to quantify using existing empirical tools. Overall, 75% of comments (...) were positive, of which 59% were supportive and 16% shared similar personal experiences. However, a subset of negative comments emerged, that provided potential insight into the reasons underlying unprofessional comments were made during the peer-review process. These comments were classified into three main themes: forced niceness will adversely impact the peer-review process and allow for publication of poor-quality science ; dismissing comments as not offensive to another person because they were not deemed personally offensive to the reader ; and authors brought unprofessional comments upon themselves as they submitted substandard work. Here, we argue against these themes as justifications for directing unprofessional comments towards authors during the peer review process. We argue that it is possible to be both critical and professional, and that no author deserves to be the recipient of demeaning ad hominem attacks regardless of supposed provocation. Suggesting otherwise only serves to propagate a toxic culture within peer review. While we previously postulated that establishing a peer-reviewer code of conduct could help improve the peer-review system, we now posit that priority should be given to repairing the negative cultural zeitgeist that exists in peer-review. (shrink)

The history of evolutionary thought / Michael Ruse -- The origin of life / Jeffrey L. Bada and Antonio Lazcano -- Paleontology and the history of life / Michael Benton -- Adaptation / Joseph Travis and David N. Reznick -- Molecular evolution / Francisco J. Ayala -- Evolution of the genome / Brian Charlesworth and Deborah Charlesworth -- The pattern and process of speciation / Margaret B. Ptacek and Shala J. Hankison -- Evolution and development / Gregory A. Wray (...) -- Social behavior and sociobiology / Daniel J. Rubenstein -- Human evolution / Henry M. McHenry -- Evolutionary biology of disease and Darwinian medicine / Michael F. Antolin -- Beyond the Darwinian paradigm : understanding biological forms / Brian Goodwin -- Philosophy of evolutionary thought / Kim Sterelny -- Evolution and society / Manfred D. Laubichler and Jane Maienschein -- Evolution and religion / David N. Livingstone -- American antievolutionism : retrospect and prospect / Eugenie C. Scott. (shrink)

Thought's Footing is an enquiry into the relationship between the ways things are and the way we think and talk about them. It is also a study of Wittgenstein's Philosophical Investigations: Charles Travis develops his account of certain key themes into a unified view of the work as a whole. The central question is: how does thought get its footing? How can the thought that things are a certain way be connected to things being that way?

What is insensitive semantics (also semantic minimalism, henceforth SM)? That will need to emerge, if at all, from the authors’ (henceforth C&L) objections to what they see as their opponents. They signal two main opponents: moderate contextualists (henceforth MCs); and radical contextualists (henceforth RCs). I am signaled as a main RC. I will thus henceforth represent that position in propria persona. In most general lines the story is this: MC collapses into RC; RC is incoherent, or inconsistent, on various counts; (...) SM is thus the only game in town. As to all of that, we shall see. (shrink)

Comment garantir l’objectivité de notre rapport au monde? Le rationalisme et l’empirisme renvoient, chacun à leur manière, à une capacité générale de l’esprit humain – capacité désengagée du monde, décontextualisée. La nouveauté radicale qu’introduit Wittgenstein dans sa seconde philosophie est une vision contextualiste et proprement humaine de l’objectivité.Dans cet ouvrage, issu de leçons données au Collège de France en 2002, Charles Travis prend appui sur Frege, Wittgenstein et J.L. Austin pour montrer que l’opération de désangagement du monde propre aux (...) différentes théories de la connaissance contemporaines ne permet plus à la pensée d’être objective et a fortiori d’être vraie. Elle ne permet pas de véritable rapport au monde. C’est plutôt au sein de nos pratiques les plus ordinaires que se fondent l’objectivité qui est la nôtre, la vérité, ainsi que les différents accords du monde avec le langage et la pensée. La vérité n’est pas abstraite, nos représentations sont situées. Toute signification, comme toute pensée, est sensible à l’occasion. Charles Travis propose ici une lecture originale de Wittgenstein, conjuguée à une approche particulière des grands problèmes de la philosophie analytique. (shrink)

“La théorie, c'est bon, mais ça n'empêche pas d'exister”J. M. CharcotRoughly speaking, references relate what is said to just those things about which it is said. A theory of reference is commonly taken to be a statement or characterization of that relation which references effect — that relation, that is, which holds between something that is said and some object just in case in that which is said reference is made to that object. Such a theory is often further conceived (...) as answering one or both of the questions: For any given object X, what is it for a reference to be made to X, and For any given reference, R, what is it for an object X to be the referent of R. Let us call a theory which correctly answers at least some of these questions a classical theory of reference. (shrink)